Take a look at some of the San Francisco 49ers best plays versus NFC West opponents of all time. San Francisco 49ers ...

Jimmy Garoppolo knows what it feels like as a San Francisco 49er to come to L.A., but now the quarterback is on the other ...

George Kittle missed practice on Thursday because of a hamstring injury. Here's the latest on the TE's status for the Week 3 ...

San Francisco 49ers fullback Kyle Juszczyk toe-tapped along the sideline to pick up a first down in the team's Week 2 matchup ...

The Niners will perhaps be without arguably their three most important offensive weapons, sidelined stars Christian McCaffrey ...

In Week 1, Juszczyk, the wife of San Francisco 49ers fullback Kyle Juszczyk, created one of her custom jackets but with a ...

Sam Darnold passed for 268 yards and two touchdowns against his former team, including a 97-yard strike in the second quarter ...

Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

Former 49ers players Richard Sherman and Donte Whitner ripped San Francisco's defense for allowing Justin Jefferson's 97-yard ...

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

Darnold passed for 268 yards and two touchdowns against his former team, including a 97-yard strike in the second quarter to ...