See who's in and who's out for the Week 3 matchup between the San Francisco 49ers and Los Angeles Rams on September 22, 2024.

Check out our Rams vs. Cardinals how to watch guide to learn when they play and what free live streams are available ahead of kickoff.

After an atrocious offensive performance in Week 1, the Cleveland Browns bounced back to defeat the Jacksonville Jaguars in Week 2. While the offense still looked underwhelming, with quarterback Deshaun Watson compiling only 5.

The San Francisco 49ers (1-1) are 6.5-point favorites when they visit the Los Angeles Rams (0-2) in an NFC West matchup on Sunday, September 22, 2024 at SoFi Stadium.NFL odds courtesy of BetMGM

According to oddsmakers, the Cleveland Browns (1-1) are less than a touchdown favorite (-6.5) on Sunday, September 22, 2024 against the New York Giants (0-2). A point total of 39.5 has been set

If there's anything to learn from Week 2, it's anything can happen in the NFL. There were eight upsets in the second week of the regular season that surely had bettors going crazy with all the unsuspected finishes in the league.

This will be a week of Davids facing Goliaths as far as betting is concerned: Seven of the 16 matchups opened with the favorite giving up at least 6.5 points to the underdog. Fire

Picks: Giants at Browns