This week, the Packers will take on the San Francisco 49ers as 5.5-point home favorites in the Week 12 NFL odds with an over-under of 44.5, one of the three NFL games in the late afternoon window. Can Love's team beat the defending NFC champions this week in a rematch from last year's Divisional Round or will his interception issues continue to plague the Packers?

Although Jordan Love has struggled all season with inconsistency, we expect the Green Bay quarterback to shine on Sunday against a 49ers team missing key pieces.

Week 12 of the 2024-25 NFL season features seven divisional matchups, multiple games with double-digit point spreads and the first “Harbaugh Bowl” in over a dozen years.