ARIZONA -- The Arizona Cardinals could be without some key contributors in their Week 3 home matchup against the Detroit Lions. The Cardinals listed Greg Dortch, Dante Stills and Kelvin Beachum as questionable after Friday's practice.

Come Sunday at State Farm Stadium, the Lions will attempt to display their resilience by avoiding their second straight setback in a Week 3 contest against the Arizona Cardinals.

For the Lions, the only starter I’m expecting to be out is Alex Anzalone. Otherwise, the Lions are healthy heading into Arizona. The Cardinals started the week with a tiny injury report but had two players suffer new hamstring injuries during the week that could impact the game.

SportsLine's model simulated Detroit Lions vs. Arizona Cardinals 10,000 times and made its Week 3 NFL picks, predictions and best bets

Both teams have beaten the Los Angeles Rams, with the Cardinals blowing out their NFC West rivals 41-10 last Sunday. Detroit needed overtime to conquer the injury-ravaged Rams, 26-20, in Week 1. The Lions offense has moved the ball very well but struggled to score points. Arizona can put up points in bunches but is vulnerable on defense.

Preview the Week 3 matchup between the Detroit Lions and Arizona Cardinals with predictions, odds, over/under, spread, betting lines and more.

Despite all of the success he's had so far, Lions coach Dan Campbell apparently hasn't won over everyone in Detroit. The Lions recently put Campbell's house on the market amid privacy and security concerns after the house's address was leaked.

Detroit Lions head coach Dan Campbell watches during the first half of an NFL football game against the Tampa Bay Buccaneers, Sunday, Sept. 15, 2024, in Detroit. (AP

Detroit Lions coach Dan Campbell said he's in the process of selling his family's suburban Motown home after amateur sleuths learned where they reside.